Samin-derived flavonolignans, a new series of antidiabetic agents having dual inhibition against α-glucosidase and free radicals.
Autor: Worawalai, Wisuttaya; Phuwapraisirisan, Preecha
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1553169
Abstract:
A series of novel flavonolignans were synthesized by the reaction between a lignan named samin (1) and a range of flavonoids. This simple and rapid approach allowed direct assembly of these two bulky motifs in good yields without the formation of byproducts. Upon evaluation of antidiabetic activity of the synthesized products, epicatechinosamin (β-2g) was the most active α-glucosidase inhibitor toward maltase and sucrase. The kinetic study indicated that β-2 g inhibited the enzymes in a mixed manner of competitive and noncompetitive inhibition.
Language: eng
Rights:
Pmid: 30618297
Tags: Kinetics; diabetes; Magnetic Resonance Spectroscopy; Molecular Structure; antioxidant; Flavonoids/chemistry; alpha-Glucosidases/metabolism; Antioxidants/chemistry/pharmacology; Flavonolignan; Flavonolignans/chemistry/*pharmacology; Free Radicals/metabolism; Friedel-Crafts; glucosidase; Glycoside Hydrolase Inhibitors/chemistry/*pharmacology; Hypoglycemic Agents/*chemistry/*pharmacology; oxocarbenium
Link: https://pubmed.ncbi.nlm.nih.gov/30618297/
