New p-terphenyl and benzoquinone metabolites from the bioluminescent mushroom Neonothopanus nambi.
Autor: Sangsopha, Watchara; Lekphrom, Ratsami; Schevenels, Florian T.; Saksirirat, Weerasak; Bua-Art, Sureeporn; Kanokmedhakul, Kwanjai; Kanokmedhakul, Somdej
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2019.1578763
Abstract:
Two new p-terphenyls, neonambiterphenyls A and B (1-2), a new benzoquinone, neonambiquinone A (3), together with six known sesquiterpenes (4-9), were isolated from the bioluminescent mushroom Neonothopanus nambi PW3. The isolated compounds were identified by mass, IR and spectroscopic analyses (1D and 2D NMR). Compounds 1-3 and 5-7 showed cytotoxicity against cancer cell lines such as KB, NCI-H187 and MCF-7 with IC(50) values ranging from 1.45 to 49.31 µg/mL. In addition, compounds 1 and 5 showed cytotoxicity against Vero cells with IC(50) values of 38.72 and 32.90 µg/mL, respectively.
Language: eng
Rights:
Pmid: 30810369
Tags: Humans; Animals; Cell Line, Tumor; Chlorocebus aethiops; Molecular Structure; Spectrum Analysis; cytotoxicity; sesquiterpene; Agaricales/*chemistry; aurisin; benzoquinone; Benzoquinones/*isolation & purification; Cytotoxins/isolation & purification; Neonothopanus nambi; p-terphenyl; Sesquiterpenes/chemistry/*isolation & purification; Vero Cells
Link: https://pubmed.ncbi.nlm.nih.gov/30810369/
