LONG-TERM MULTIMODAL IMAGING OF OCULAR FINDINGS ASSOCIATED WITH THIAMINE-RESPONSIVE MEGALOBLASTIC ANEMIA.
Autor: Tsui, Edmund; Tauber, Jenna; Barbazetto, Irene; Gelman, Susan K.
Publication year: 2020
Retinal cases & brief reports
issn:1937-1578 1935-1089
doi: 10.1097/ICB.0000000000000686
Abstract:
PURPOSE: To report on 5-year multimodal imaging of ocular findings in a patient with thiamine-responsive megaloblastic anemia. METHODS: Observational case report. RESULTS: A 20-year-old-man with a history of thiamine-responsive megaloblastic anemia demonstrated a symmetric bull’s eye maculopathy. Spectral domain optical coherence tomography revealed disruption of the parafoveal ellipsoid zone, fundus autofluorescence demonstrated foveal hypoautofluorescence, and full-field electroretinogram testing revealed a decreased photopic and scotopic response consistent with cone-rod dystrophy. His best-corrected visual acuity remained stable over 5 years at 20/50 in the right eye and 20/40 in the left eye, and visual field testing remained stable over time. CONCLUSION: Ocular manifestations in thiamine-responsive megaloblastic anemia are uncommon and variable. In this case, multimodal imaging and electroretinogram findings are consistent with cone-rod degeneration. The patient is taking daily thiamine supplementation, and visual acuity, funduscopic examination, spectral domain optical coherence tomography, and autofluorescence remained stable over a 5-year period.
Language: eng
Rights:
Pmid: 29210962
Tags: Humans; Male; Time Factors; Young Adult; Follow-Up Studies; Disease Progression; *Visual Acuity; Fundus Oculi; Tomography, Optical Coherence/methods; Fluorescein Angiography/methods; Anemia, Megaloblastic/complications/*drug therapy; Electroretinography/methods; Multimodal Imaging/*methods; Ophthalmoscopy; Retinal Diseases/*diagnosis/etiology; Thiamine/*therapeutic use
Link: https://pubmed.ncbi.nlm.nih.gov/29210962/
