Association between the lactate/albumin ratio and mortality in pediatric septic shock patients with underlying chronic disease: retrospective pilot study.
Autor: Choi, Seung J.; Ha, Eun-Ju; Jhang, Won K.; Park, Seong J.
Publication year: 2021
Minerva pediatrics
issn:2724-5780
doi: 10.23736/S2724-5276.16.04551-5
Abstract:
BACKGROUND: We aimed to evaluate the ability of the lactate/albumin ratio to predict mortality in pediatric septic shock patients. METHODS: Retrospective analysis of the medical records of a pediatric intensive care unit. The study cohort comprised 90 pediatric septic shock patients admitted from February 2012 to May 2015. RESULTS: The serum lactate and albumin levels and lactate/albumin ratio were compared between survivors and non-survivors. We assessed whether the lactate/albumin ratio could be used to predict mortality. The 28-day hospital mortality was 26.7% (24/90). The lactate level was higher (2.5±2.2 vs. 8.1±5.1 mmol/L, P<0.001) and the albumin level was lower (2.9±0.5 vs. 2.7±0.5 mg/dL, P=0.063) in non-survivors than in survivors. The lactate/albumin ratio was 0.9±0.8 in survivors and 3.2±2.4 in non-survivors (P<0.001). According to the area under the receiver operating characteristic curve (AUC), the lactate/albumin ratio showed good discriminatory power for predicting mortality (AUC=0.867). A lactate/albumin ratio exceeding 1.016 led to a 7.636-fold increase in mortality. CONCLUSIONS: The lactate/albumin ratio is a useful predictor of mortality in pediatric septic shock patients. Language: eng Rights: Pmid: 27405903 Tags: Humans; Female; Male; Retrospective Studies; Child; Adolescent; Child, Preschool; Infant; Chronic Disease; Pilot Projects; Hospital Mortality; Lactic Acid/*blood; Serum Albumin/*analysis; Shock, Septic/*blood/complications/*mortality Link: https://pubmed.ncbi.nlm.nih.gov/27405903/
