AA amyloidosis associated with morbid obesity (clinical case).

Autor: Beridze Vaktangova, Nana; García Moreira, Vanesa; García Castañón, Sandra; Rodríguez Aguilar, Raúl; Domínguez Iglesias, Francisco

Publication year: 2020

Reumatologia clinica

issn:2173-5743

doi: 10.1016/j.reuma.2018.09.001

Abstract:

We present the case of a 45-year-old woman who was hospitalized due to severe macrocytic anemia and renal failure. The patient presented a morbid obesity. The immunological study showed anti-ENA anti-SSA (Ro52) positive, with negative antinuclear antibodies. Also in the proteinogram (serum immunofixation) the presence of monoclonal bands IgG lambda and IgG kappa, monoclonal component 7.2% (4.68g/L), with elevation of free light chains (kappa 95.94mg/L (3.3-19.4), evidenced, lambda 145.17mg/L (5.71-26.3)). The bone marrow study showed an infiltration of 5% of plasma cells and positive for AA amyloid. Finally, a percutaneous renal biopsy was performed, which again showed amyloid infiltration. In the genetic study, 2 mutations of the family Mediterranean fever gene (MEFV) have been identified. Secondary AA amyloidosis has been described associated with obesity, in addition to a percentage of cases of unknown etiology.

Language: spa

Pmid: 30527964

Tags: Humans; Female; Middle Aged; Obesity; Obesity, Morbid/*complications; Amiloidosis; Amyloidosis; Amyloidosis/*etiology; Familial Mediterranean fever; Fiebre Mediterránea Familiar; Obesidad; Serum Amyloid A Protein

Link: https://pubmed.ncbi.nlm.nih.gov/30527964/