Valtrate from Valeriana jatamansi Jones induces apoptosis and inhibits migration of human breast cancer cells in vitro.
Autor: Tian, Shasha; Wang, Zhizi; Wu, Zeqi; Wei, Yingying; Yang, Bo; Lou, Siyue
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1548454
Abstract:
Valtrate is a principle compound isolated from Valeriana jatamansi Jones, a traditional Chinese folk medicine originally used to treat various nervous disorders. Here, we found that valtrate exhibited significant anti-cancer activity in vitro, especially in human breast cancer cells, while displayed relatively low cytotoxicity to normal human breast epithelial cells (MCF 10A). Valtrate induced cell cycle arrest at G2/M stage and apoptosis in MDA-MB-231 and MCF-7 cells, with reduced expression of p-Akt (Ser 473), cyclin B1 and caspase 8, and increased expression of p21, p-cdc2, cleaved-caspase 3, cleaved-caspase 7 and poly (ADP-ribose) polymerase (PARP). In addition, valtrate inhibited cell migration through down-regulation of MMP-9 and MMP-2 expression. These results demonstrate that valtrate possesses anti-breast cancer activities via cell cycle arrest, apoptosis, and inhibition of cell migration, thus supporting valtrate as a potential antitumor agent.
Language: eng
Rights:
Pmid: 30638055
Tags: Humans; apoptosis; Apoptosis/*drug effects; breast cancer; migration; Cell Movement/*drug effects; Cell Cycle Checkpoints/drug effects; MCF-7 Cells; Antineoplastic Agents, Phytogenic/*isolation & purification/pharmacology; Breast Neoplasms/drug therapy/*pathology; Caspase 8/metabolism; Epithelial Cells/drug effects; Iridoids/isolation & purification/*pharmacology; Valerian/*chemistry; Valtrate
Link: https://pubmed.ncbi.nlm.nih.gov/30638055/
