Two new bioactive lignans from leaves and twigs of Cleistanthus concinnus Croizat.
Autor: Fan, Shi-Rui; Guo, Jing-Jing; Wang, Yi-Ting; Yang, Bi-Juan; Chen, Duo-Zhi; Hao, Xiao-Jiang
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2019.1569663
Abstract:
Two new lignans (1-2), along with five known compounds (3-7) with different structures were isolated from leaves and twigs of Cleistanthus concinnus Croizat. The new lignans were elucidated as (7’R,8’S)-3,3′,5′-trimethoxy-4,4′-dihydroxy-7-en-7′,9- epoxy-8,8′-lignan (1) and (7’R,8’S)-3,3′-dimethoxy-4,4′-dihydroxy-7-en-7′,9-epoxy-8, 8′-lignan (2) by comprehensive spectroscopic analysis including 1D and 2D NMR as well as HREIMS and comparing their NMR data with known compounds in the literature. Among these isolated compounds, compound 1, 2, 3, and 6 were tested for anti- inflammatory effects by inhibiting NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Compound 1, 2, and 6 exhibit NO inhibitory activity.[Formula: see text].
Language: eng
Rights:
Pmid: 30720345
Tags: Animals; Mice; China; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Leaves/chemistry; Drug Evaluation, Preclinical; lignans; RAW 264.7 Cells; Anti-Inflammatory Agents, Non-Steroidal/chemistry/pharmacology; Cleistanthus concinnus Croizat; Euphorbiaceae; Euphorbiaceae/*chemistry; Lignans/*chemistry/*pharmacology; Lipopolysaccharides/pharmacology; Nitric Oxide/metabolism; NO inhibitory activity
Link: https://pubmed.ncbi.nlm.nih.gov/30720345/
