The role of 5-methoxytryptophan in pediatric-onset lupus nephritis: A retrospective cohort study.

Autor: Lin, Ting-Chun; Kuo, Cheng-Chin; Wu, Chao-Yi; Yeh, Kuo-Wei; Kuo, Ming-Ling; Huang, Jing-Long

Publication year: 2020

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

issn:1995-9133 1684-1182

doi: 10.1016/j.jmii.2018.12.003

Abstract:

BACKGROUND: This clinical study investigates the role of 5-methoxytryptophan (5-MTP) in pediatric systemic lupus erythematosus (SLE), with a particular interest in lupus nephritis (LN). PATIENTS AND METHODS: One hundred ten children with SLE were enrolled in the cohort study. Among the patients, seventy-seven (70%) had active LN and thirty-three (30%) were not present with LN during their first visit to the clinic. The diagnoses of LN were biopsy-proven. Serum samples were collected before and after administration of immunosuppressive medications to evaluate 5-MTP levels and regular laboratory data. Data were analyzed longitudinally. RESULTS: Before any treatment started, patients with active LN had significantly higher 5-MTP levels as compared to patients with no LN (1.021 ± 0.709 vs. 0.719 ± 0.606, P = 0.0456). Also, in patient with active LN, 5-MTP level was significant decreased after treatment, compared with the levels before treatment (1.021 ± 0.709 vs. 0.802 ± 0.597, P = 0.0484). Patients who reached complete remission also had significantly higher initial serum 5-MTP levels than that in patients with no remission (1.244 ± 0.784 vs. 0.846 ± 0.556, P = 0.0488). There was an overall reduction in 5-MTP levels after six months of immunosuppressive treatment, regardless of the disease outcome. Subgroup analysis further revealed a significantly higher 5-MTP level during the active stage of LN (1.127 ± 0.149 vs. 0.742 ± 0.092, P = 0.0384). CONCLUSION: We demonstrated that serum 5-MTP level is positively correlated to the disease activity, prognosis, and remission status of pediatric LN in vivo.

Language: eng

Pmid: 30630711

Tags: Humans; Female; Male; Retrospective Studies; Child; Adolescent; Prognosis; Biopsy; Antibodies; Lupus nephritis; Systemic lupus erythematosus; 5-methoxytryptophan (5-MTP); Immunosuppressive Agents; Lupus Nephritis/*drug therapy; Pediatric-onset; Retrospective cohort; Tryptophan/*analogs & derivatives/*pharmacology

Link: https://pubmed.ncbi.nlm.nih.gov/30630711/