The chemical components of Coreopsis tinctoria Nutt. and their antioxidant, antidiabetic and antibacterial activities.
Autor: Begmatov, Nurmirza; Li, Jun; Bobakulov, Khayrulla; Numonov, Sodik; Aisa, Haji Akber
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1525377
Abstract:
Seventeen compounds were isolated from the capitula of Coreopsis tinctoria Nutt. with various column chromatographic methods and semi-preparative HPLC. Their structures were identified by the spectroscopic data and comparison with literatures as 2′-hydroxy-4,4′-dimethoxy-chalcone; (1), isoliquiritigenin (2), eriodictyol (3), naringenin (4), maritimetin (5), butin (6), taxifolin (7), luteolin (8), 7,3′,4′-trihydroxyflavone (9), 8,3′,4′-trihydroxyflavone-7-O-β-d-glucoside (10), quercetin (11), quercetagitin-7-O-β-d-glucoside (12), quercetin-7-O-β-d-glucoside (13), 3,4-dihydroxybenzoic acid (14), caffeic acid (15), coreoside B (16), and myo-inositol (17). Compounds 1, 4, 9, 10 and 17 were isolated from C. tinctoria Nutt. for the first time. Compounds 7 and 12 possessed the highest antioxidant activity (IC(50) = 64.37 and 32.86 µg/ml, respectively) among the tested compounds (IC(50) value of positive control was 5.34 µg/ml). Compound 7 exhibited potent PTP1B enzymatic inhibition with an IC(50) value of 7.73 μg/ml (IC(50) value of positive control is 1.46 µg/ml). Furthermore, compound 5 showed strong antibacterial activity against the Gram-positive bacterium, S. aureus.
Language: eng
Rights:
Pmid: 30499349
Tags: Molecular Structure; antioxidant; Plant Extracts/chemistry; Staphylococcus aureus/drug effects; Antioxidants/chemistry/*isolation & purification/pharmacology; Flavonoids/isolation & purification; Anti-Bacterial Agents/chemistry/*isolation & purification/pharmacology; antibacterial; antidiabetic; chemical components; Coreopsis tinctoria Nutt.; Coreopsis/*chemistry; Glucosides/isolation & purification; Hypoglycemic Agents/chemistry/*isolation & purification/pharmacology; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors; PTP1B enzymatic inhibition
Link: https://pubmed.ncbi.nlm.nih.gov/30499349/
