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CoinsKey Strategies for Finding the Next Multi-Bagger StockTop Dividend Stocks for Conservative Investors: Coca-Cola, Waste Management, and American Electric PowerChicken Offerings Drive Growth at McDonald’sJenna Phipps Explores DIY Successes and Challenges in Home Renovation SeriesAutomakers Focus on Parts Sourcing as Consumers Remain UnawareChina Eases Import Taxes Following Carmaker ProtestsHow Investing £500 Monthly Over 5 Years Could Have Generated Significant Passive IncomeWarren Buffett Reveals New Investments Amid US Market RecoveryMike Jeffries Deemed Mentally Incompetent, Hospitalized for EvaluationMultiple Insiders Purchase Shares Signaling Confidence in Company’s FutureTrump Downplays Recession Fears, Says Long-Term Economy Will Be ‘OK’Mega Millions Winning Numbers for May 2, 2025 Drawing RevealedStock Market Rallies Ahead of Buffett Appearance, Palantir Earnings, and Fed MeetingOver 1,000 New Full-Time Jobs Announced With Competitive Pay and Wellness BenefitsMcDonald’s CEO 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Mon. May 5th, 2025
Trending News: Stock Futures Start the Week Flat Ahead of Key Economic DataWhy a 5% Bitcoin Allocation May Strengthen Your Investment PortfolioTomatoes Recalled in 11 States Over Salmonella ConcernsUncork Capital Closes $300 Million Across Two New FundsMirova Launches New Nature-Based Carbon Funds Amid Growing Interest in ESG InvestingGeneral Motors Recalls Nearly 600,000 Trucks and SUVs Over Engine DefectUnderstanding Mutual Funds as an Investment StrategyMarvel’s ‘Thunderbolts’ Tops Box Office With $76 Million DebutWarren Buffett Leads Berkshire Hathaway for Six Decades, Building Trillion-Dollar EmpireSustainable Investing Remains Resilient Amid Market Challenges, Says Mirova ExecutiveU.S. Stock Market Rebounds to Pre-‘Liberation Day’ LevelsUS Stock Market Recovers to Trump’s ‘Liberation Day’ LevelsWall Street Strategists Question ‘Sell in May’ Market AdageHumor as a Coping Mechanism: ‘Recession Indicator’ Memes Go Viral Amid Economic UncertaintySustainable Investing Remains Strong Despite Market ChallengesWarren Buffett-Backed Stocks That Can Weather Any Market ConditionsS&P 500 Achieves Longest Winning Streak in Two DecadesBerkshire Hathaway Shareholders Express Concern Over Buffett’s DepartureGen Z Turns to Hermès Birkin Bags as Alternative Investment, Driven by TikTok FrenzyCanadian Prime Minister Outlines Strategy to Address Trump PoliciesHistoric Divergence Emerges as Gold Surges and U.S. Stocks LagWarren Buffett Announces Plan to Step Down as Berkshire Hathaway CEO by Year-EndWarren Buffett’s Six-Decade Legacy at Berkshire HathawaySNL Skewers Donald Trump in Sketch Imagining Him as the PopeSeaport Global Downgrades Nvidia to ‘Sell’, Issues Lowest Price Target on Wall StreetWarren Buffett Names Greg Abel as Successor at Berkshire HathawayUber Introduces Cash Payment Option Following Trial SuccessCanadian Prime Minister Outlines Strategy for Dealing with Donald TrumpWarren Buffett Reaffirms Faith in U.S. Economy Amid Market VolatilityWarren Buffett to Step Down as CEO of Berkshire HathawayWarren Buffett to Step Down as CEO of Berkshire Hathaway by Year-EndWarren Buffett to Step Down as CEO of Berkshire Hathaway by Year-EndResidents Vote on Incorporating New Town with SpaceX Employee as Potential MayorVoice of America Staff Regain System Access After DisruptionsLouisiana Representative Proposes House Bill 386Tomatoes Recalled Across Southeastern U.S. Over Salmonella ConcernsThe Influence of Personal Networks on Career and Life TrajectoriesInvestor Confidence Drops Amid Market Volatility and Recession FearsS&P 500 Posts Longest Winning Streak in Over 20 YearsThe Importance of Long-Term Investing Amid Short-Term Stock SetbacksBerkshire Hathaway’s Annual Meeting Draws Attention for Its Unique StyleUnderstanding the Risks of Investing in Company SharesWorld Press Freedom Day Marked by Renewed Concerns Over Media IntimidationIBM Announces $150 Billion Investment Over Five YearsCoinstar CEO Calls for Rethinking America’s Relationship with CoinsKey Strategies for Finding the Next Multi-Bagger StockTop Dividend Stocks for Conservative Investors: Coca-Cola, Waste Management, and American Electric PowerChicken Offerings Drive Growth at McDonald’sJenna Phipps Explores DIY Successes and Challenges in Home Renovation SeriesAutomakers Focus on Parts Sourcing as Consumers Remain UnawareChina Eases Import Taxes Following Carmaker ProtestsHow Investing £500 Monthly Over 5 Years Could Have Generated Significant Passive IncomeWarren Buffett Reveals New Investments Amid US Market RecoveryMike Jeffries Deemed Mentally Incompetent, Hospitalized for EvaluationMultiple Insiders Purchase Shares Signaling Confidence in Company’s FutureTrump Downplays Recession Fears, Says Long-Term Economy Will Be ‘OK’Mega Millions Winning Numbers for May 2, 2025 Drawing RevealedStock Market Rallies Ahead of Buffett Appearance, Palantir Earnings, and Fed MeetingOver 1,000 New Full-Time Jobs Announced With Competitive Pay and Wellness BenefitsMcDonald’s CEO Acknowledges Consumer Uncertainty Amid Economic ShiftsInvestor Caution Rises Amid Strong Labor Data and Inflation ConcernsBig Lots Locations Reopen Under New Ownership Following BankruptcyHousehold Appliance Maker Reports Over 100 Burn Injuries Linked to ProductOpenAI Rolls Back ChatGPT Update Following User Backlash Over Excessive FlatteryWarehouse Club Traffic Rises Amid Tariff ConcernsTake-Two Delays ‘Grand Theft Auto VI’ Release to May 2026, Shares Drop 8%E-Commerce Surge Raises Concerns Over Child Safety, Advocates WarnWhy Having a Retirement Plan Is Essential, According to Financial ExpertsChinese Carmakers Emerge as Leaders in Global Electric Vehicle IndustryFord Reports 16% Surge in April Sales, Driven by Pickup DemandAvient Corporation Stock Shows Steady Performance Despite Modest GainsU.S. Stock Futures Rise on Hopes of Renewed U.S.-China Trade TalksKrispy Kreme Offering Free Doughnuts on May 7 for Real ID DeadlineEuropean and Global Markets Outlook: Key Trends to WatchInvesting Strategy Highlights Benefits of Identifying Undervalued StocksTrump Signs Executive Order to End Federal Funding for NPR and PBSTrump’s Tariff Policies May Increase U.S. Inflation While Easing It in EuropeKrispy Kreme to Give Away Free Doughnuts Ahead of Real ID DeadlineMarket Outlook: Investors Eye Global Earnings and Central Bank MovesInvestors Seek Market Outperformance Through Undervalued StocksTrump Signs Executive Order to End Federal Funding for NPR and PBSTrump’s Tariff Policy Could Raise U.S. Inflation While Easing It in EuropeMaryland Bakery Recalls Bread Sold in Six States Over Glass ContaminationJeff Bezos-Backed Startup Slate Auto Unveils Affordable Electric Pickup TruckMarkets See Historic Volatility Since ‘Liberation Day’New Starbucks Store to Open in Brownsville, Texas on May 2U.S. Economy Contracts Faster Than Expected, Raising Recession Concerns5 Key Factors to Consider Before Investing in Gold TodayUS Stocks Fall as Markets Await Big Tech Earnings and React to Tariff AnnouncementApril Sees Unprecedented Volatility Across Global MarketsBay County Locals Debate Ending Spring Break FestivitiesSnack Food Companies See Slump in Sales Amid Shifting Consumer TrendsSocial Security Officials Address Increase in Benefit Claims in Leaked Meeting VideoConsumers Misled by Fintechs Promising FDIC InsuranceTrump’s Tariff Policies Likely Slowed U.S. Economy in Early 2024Business Leaders Quietly Navigate Second Trump Term Amid ControversiesCoffee Giant Plans to Hire More Staff Amid Falling SalesPGGM Advances Impact Investing Strategy with Total Portfolio ApproachInvestors Shift Focus to Latin American Currencies and Gold Amid Policy UncertaintyWall Street Steady Ahead of Big Tech Earnings and Tariff Developments
Mon. May 5th, 2025

The antidepressant effect of 4-hydroxybenzyl alcohol 2-naphthoate through monoaminergic, GABAergic system and BDNF signaling pathway.

  • PubMed
  • May 4, 2025
  • 0 Comments

The antidepressant effect of 4-hydroxybenzyl alcohol 2-naphthoate through monoaminergic, GABAergic system and BDNF signaling pathway.

Autor: Zhang, Di; Zhu, Hong-Yan; Bian, Xing-Bo; Zhao, Yan; Zang, Pu; Gao, Yu-Gang; Zhang, Lian-Xue

Publication year: 2020

Natural product research

issn:1478-6427 1478-6419

doi: 10.1080/14786419.2018.1531862

Abstract:

Gastrodigenin, also known as 4-hydroxybenzyl alcohol (HBA), is one of the main components of Gastrodia elata, which is a perfect lead compound of natural products. In order to get new active compounds, we modified the structure of HBA through esterification with carboxylic acid, and got a series of derivatives in which 4-hydroxybenzyl alcohol 2-naphthoate (NHBA) showed stronger antidepressant activity than HBA. In this paper, we firstly evaluated the antidepressant activity of NHBA by tail suspension test (TST) and forced swimming test (FST). Then, we carried out the biochemical assay and western blot to determine its mechanism. The results displayed that NHBA could increase the content of serotonin, dopamine, norepinephrine, γ-aminobutyric acid, brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) in mice brain. It suggested that NHBA exhibited an antidepressant-like effect through monoaminergic system, GABAergic system and BDNF/TrkB signaling pathways.

Language: eng

Rights:

Pmid: 30580589

Tags: Animals; Mice; Brain/*metabolism; Swimming; Brain-Derived Neurotrophic Factor/*metabolism; Signal Transduction/*drug effects; antidepressant effect; Antidepressive Agents/chemistry/*pharmacology; BDNF/TrkB signaling pathways; Benzyl Alcohols/chemistry/*pharmacology; Biogenic Monoamines/metabolism; gamma-Aminobutyric Acid/metabolism; Gastrodia/chemistry; gastrodigenin; Hindlimb Suspension; monoaminergic system

Link: https://pubmed.ncbi.nlm.nih.gov/30580589/

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