TAMOXIFEN RETINOPATHY DURING TREATMENT OF AN INOPERABLE DESMOID TUMOR.
Autor: Furst, Meredith; Somogyi, Marie B.; Wong, Robert W.; Araujo, Dejka; Harper, Clio A. 3rd
Publication year: 2020
Retinal cases & brief reports
issn:1937-1578 1935-1089
doi: 10.1097/ICB.0000000000000691
Abstract:
PURPOSE: To evaluate the clinical significance and rarity of tamoxifen retinopathy after a long-term tamoxifen treatment for an inoperable desmoid tumor. METHODS: Case report. RESULTS: Tamoxifen retinopathy is a condition rarely observed in clinical practice. Although tamoxifen is typically a treatment for breast cancer patients, we present a 68-year-old woman taking tamoxifen for an inoperable desmoid tumor, an equally rare condition. She presented with bilaterally deteriorating vision over the course of a year. Fundoscopic examination revealed parafoveal deposits bilaterally. Spectral domain optical coherence tomography exhibited hyperreflective deposits in all layers of the retina. She had a cumulative treatment dose of 292 g of tamoxifen, and the medication was subsequently stopped. Her vision remained stable 3 months after the cessation of tamoxifen. CONCLUSION: The development of tamoxifen retinopathy in the treatment of a desmoid tumor makes this case a rare entity, and this is the first reported case of these two concomitant conditions to our knowledge. With the use of long-term tamoxifen as a primary treatment, we recommend screening at regular intervals by an ophthalmologist as an integral part of treatment.
Language: eng
Rights:
Pmid: 29227350
Tags: Humans; Aged; Female; *Visual Acuity; Fluorescein Angiography; Fundus Oculi; Tomography, Optical Coherence/methods; *Neoplasm Staging; Antineoplastic Agents, Hormonal/adverse effects/therapeutic use; Breast Neoplasms/diagnosis/*drug therapy; Desmoid Tumors/diagnosis/*drug therapy; Retina/drug effects/*pathology; Retinal Diseases/*chemically induced/diagnosis; Tamoxifen/*adverse effects/therapeutic use
Link: https://pubmed.ncbi.nlm.nih.gov/29227350/
