Quantification of myocardial blood flow with (11)C-hydroxyephedrine dynamic PET: comparison with (15)O-H(2)O PET.
Autor: Hiroshima, Yuji; Manabe, Osamu; Naya, Masanao; Tomiyama, Yuuki; Magota, Keiichi; Obara, Masahiko; Aikawa, Tadao; Oyama-Manabe, Noriko; Yoshinaga, Keiichiro; Hirata, Kenji; Kroenke, Markus; Tamaki, Nagara; Katoh, Chietsugu
Publication year: 2020
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
issn:1532-6551 1071-3581
doi: 10.1007/s12350-017-1140-4
Abstract:
BACKGROUND: (11)C-hydroxyephedrine (HED) PET has been used to evaluate the myocardial sympathetic nervous system (SNS). Here we sought to establish a simultaneous approach for quantifying both myocardial blood flow (MBF) and the SNS from a single HED PET scan. METHODS: Ten controls and 13 patients with suspected cardiac disease were enrolled. The inflow rate of (11)C-HED (K1) was obtained using a one-tissue-compartment model. We compared this rate with the MBF derived from (15)O-H(2)O PET. In the controls, the relationship between K(1) from (11)C-HED PET and the MBF from (15)O-H(2)O PET was linked by the Renkin-Crone model. RESULTS: The relationship between K(1) from (11)C-HED PET and the MBF from (15)O-H(2)O PET from the controls’ data was approximated as follows: K(1) = (1 – 0.891 * exp(- 0.146/MBF)) * MBF. In the validation set, the correlation coefficient demonstrated a significantly high relationship for both the whole left ventricle (r = 0.95, P < 0.001) and three coronary territories (left anterior descending artery: r = 0.96, left circumflex artery: r = 0.81, right coronary artery: r = 0.86; P < 0.001, respectively). CONCLUSION: (11)C-HED can simultaneously estimate MBF and sympathetic nervous function without requiring an additional MBF scan for assessing mismatch areas between MBF and SNS. Language: eng Rights: Pmid: 29270771 Tags: Humans; Prospective Studies; Adult; Water; *Radiopharmaceuticals; 11C-hydroxyephedrine; 15O-H2O; Carbon Radioisotopes; cardiac disease; Coronary Circulation/*physiology; Ephedrine/analogs & derivatives; Oxygen Radioisotopes; PET; Positron-Emission Tomography/*methods; regional myocardial blood flow; sympathetic nerve system; Sympathetic Nervous System/physiology Link: https://pubmed.ncbi.nlm.nih.gov/29270771/
