Prognostic factors, treatment, and survival in cutaneous pleomorphic sarcoma.
Autor: Ibanez, Maria A.; Rismiller, Kyle; Knackstedt, Thomas
Publication year: 2020
Journal of the American Academy of Dermatology
issn:1097-6787 0190-9622
doi: 10.1016/j.jaad.2018.08.054
Abstract:
BACKGROUND: Limited information exists on the influence of demographics, tumor characteristics, and treatment on survival in cutaneous pleomorphic sarcoma (CPS). OBJECTIVE: To describe incidence rates and prognostic factors affecting survival in CPS. METHODS: National Cancer Institute’s Surveillance, Epidemiology, and End Results data (1972-2013) was analyzed for 2423 patients with CPS diagnoses. RESULTS: The age-adjusted incidence rate was 0.152 cases/100,000 person-years and was 4.5-fold higher in male than female patients. Male sex, white race, and increasing age >40 years were significantly associated with decreased overall survival. Head and neck tumors, tumors >15 mm, and tumors with grade III or IV histology were associated with significantly decreased survival. Surgical excision had a survival benefit compared with no treatment. Radiation therapy did not provide a survival benefit. Patients with localized disease had the greatest survival followed by regional and distant disease. LIMITATIONS: Surveillance, Epidemiology, and End Results data might not be reflective of all CPS patients. Recurrences, restaging, or other nonmortality events over time were not tracked. CONCLUSION: Tumor size, grade, sex, age at diagnosis, and race appear to influence survival as prognostic factors in CPS. Surgical tumor extirpation provides a survival benefit over no treatment whereas primary or adjuvant radiation does not provide a survival benefit.
Language: eng
Rights: Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Pmid: 30414918
Tags: Humans; Aged; Aged, 80 and over; Female; Male; Adult; Middle Aged; Adolescent; Young Adult; Prognosis; Risk Factors; treatment; epidemiology; Sex Factors; Age Factors; United States/epidemiology; Kaplan-Meier Estimate; demographics; Cryosurgery/statistics & numerical data; Laser Therapy/statistics & numerical data; Mohs Surgery/statistics & numerical data; Neoadjuvant Therapy/methods/statistics & numerical data; Neoplasm Grading; Neoplasm Recurrence, Local/*epidemiology/prevention & control; prognostic factors; Radiotherapy, Adjuvant/statistics & numerical data; Sarcoma/diagnosis/*mortality/pathology/*therapy; SEER Program/statistics & numerical data; Skin Neoplasms/diagnosis/*mortality/pathology/*therapy; Skin/pathology; Tumor Burden; undifferentiated pleomorphic sarcoma
Link: https://pubmed.ncbi.nlm.nih.gov/30414918/
