Perfusion weighted imaging using combined gradient/spin echo EPIK: Brain tumour applications in hybrid MR-PET.
Autor: Shah, N. Jon; da Silva, Nuno André; Yun, Seong Dae
Publication year: 2021
Human brain mapping
issn:1097-0193 1065-9471
doi: 10.1002/hbm.24537
Abstract:
Advanced perfusion-weighted imaging (PWI) methods that combine gradient echo (GE) and spin echo (SE) data are important tools for the study of brain tumours. In PWI, single-shot, EPI-based methods have been widely used due to their relatively high imaging speed. However, when used with increasing spatial resolution, single-shot EPI methods often show limitations in whole-brain coverage for multi-contrast applications. To overcome this limitation, this work employs a new version of EPI with keyhole (EPIK) to provide five echoes: two with GEs, two with mixed GESE and one with SE; the sequence is termed “GESE-EPIK.” The performance of GESE-EPIK is evaluated against its nearest relative, EPI, in terms of the temporal signal-to-noise ratio (tSNR). Here, data from brain tumour patients were acquired using a hybrid 3T MR-BrainPET scanner. GESE-EPIK resulted in reduced susceptibility artefacts, shorter TEs for the five echoes and increased brain coverage when compared to EPI. Moreover, compared to EPI, EPIK achieved a comparable tSNR for the first and second echoes and significantly higher tSNR for other echoes. A new method to obtain multi-echo GE and SE data with shorter TEs and increased brain coverage is demonstrated. As proposed here, the workflow can be shortened and the integration of multimodal clinical MR-PET studies can be facilitated.
Language: eng
Rights: © 2019 Wiley Periodicals, Inc.
Pmid: 30761676
Tags: Humans; Brain Neoplasms/*diagnostic imaging; *Echo-Planar Imaging/methods/standards; *Image Processing, Computer-Assisted/methods/standards; *Perfusion Imaging/methods/standards; EPIK; gradient echo/spin echo; image distortion; MR-PET; multi-contrast; Multimodal Imaging/methods/standards; Positron-Emission Tomography/methods/standards
Link: https://pubmed.ncbi.nlm.nih.gov/30761676/
