New alkaloids and isocoumarins from the marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501.
Autor: Ma, Xuan; Liang, Xiao; Huang, Zhong-Hui; Qi, Shu-Hua
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2019.1569660
Abstract:
Two new β-carboline alkaloids, aspergillspins A-B (1-2), three new quinolone alkaloids, aspergillspins C-E (3-5), and two new isocoumarins, aspergillspins F-G (6-7), together with four known alkaloids were isolated from the marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501. Their structures were identified by spectroscopic analysis, and the absolute configurations of several chiral carbons in 2 and 3 were further established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Their cytotoxic and antibacterial activities were also evaluated.
Language: eng
Rights:
Pmid: 30761921
Tags: Circular Dichroism; Molecular Structure; Molecular Conformation; Anti-Bacterial Agents/chemistry/*isolation & purification/pharmacology; Aspergillus/*chemistry; Fungi/chemistry; Alkaloids/*isolation & purification; Aquatic Organisms/chemistry; Aspergillus sp.; Cytotoxins/chemistry/*isolation & purification/pharmacology; isocoumarin; Isocoumarins/chemistry/*isolation & purification; Marine-derived fungus; quinolone alkaloid; β-carboline alkaloid
Link: https://pubmed.ncbi.nlm.nih.gov/30761921/
