N-Alkylamides from Piper longum L. and their stimulative effects on the melanin content and tyrosinase activity in B16 melanoma cells.
Autor: Abdubakiev, Sardorbek; Li, Hongliang; Lu, Xueying; Li, Jun; Aisa, H. A.
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1539982
Abstract:
Piper longum L., known as long pepper, is an edible and medicinal plant used as spice and for the treatment of stomach disease and analgesia in traditional Chinese medicine. N-Alkylamides are the major secondary metabolites in this plant. Sixteen known N-alkylamides were isolated from P. longum. Their structures were established on the basis of spectroscopic data and comparison to reported literatures. Among them, five compounds were isolated from this plant for the first time. Ethanol extract, compounds 1, 2, 3, 7 and 11 exhibited potent ability to increase the melanin content and weak stimulative effect on the tyrosinase activity in a concentration-dependent manner. Moreover, compound 2 also presented strong capacity to increase the tyrosinase activity in a concentration-dependent manner. These results indicated that P. longum might be a good natural source of lead compound for skin disorder diseases.
Language: eng
Rights:
Pmid: 30623685
Tags: Humans; Animals; Mice; Cell Line, Tumor; Ethanol/chemistry; Medicine, Chinese Traditional; Plant Extracts/chemistry/*pharmacology; Amides/isolation & purification/*pharmacology; melanin content; Melanins/*metabolism; Melanoma, Experimental/*drug therapy/metabolism; Monophenol Monooxygenase/*drug effects/metabolism; N-alkylamides; Piper longum L.; Piper/*chemistry; tyrosinase activity
Link: https://pubmed.ncbi.nlm.nih.gov/30623685/
