Metabolic Monitoring of Child and Adolescent Patients on Atypical Antipsychotics by Psychiatrists and Primary Care Providers.

Metabolic Monitoring of Child and Adolescent Patients on Atypical Antipsychotics by Psychiatrists and Primary Care Providers.

Autor: Wakefield, Sarah; Aligeti, Manish; Rachamallu, Vivekananda; Baronia, Regina; Aynampudi, Ram; Parmar, Ankit; Peterson, Phyllis; Masodkar, Kanak

Publication year: 2020

American journal of therapeutics

issn:1536-3686 1075-2765

doi: 10.1097/MJT.0000000000000853

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Abstract:

BACKGROUND: Antipsychotic drug use in children has doubled from 2001 to 2007 with concomitant increase in obesity. Second-generation antipsychotic (SGA) medication use is associated with weight gain, metabolic derangements, and blood sugar and lipid abnormalities in children. The American Psychiatric Association and the American Diabetes Association have recommended metabolic monitoring guidelines for patients using SGA. STUDY QUESTION: The study objective was to investigate and compare metabolic monitoring for SGA medications in psychiatry (PSY), and pediatrics and family medicine [primary care providers (PCP)] outpatient clinics of a university medical center. STUDY DESIGN: This is a retrospective study of 149 charts of patients newly prescribed with SGA, ages 5-18 years, from their initial visit in the outpatient clinics. MEASURES AND OUTCOMES: Compliance with recommended metabolic monitoring was evaluated for initial and subsequent clinic visits. Parameters included body mass index, waist circumference, blood pressure, fasting plasma glucose, and fasting lipid profile. RESULTS: Of the 149 charts, 110 patients were in PSY and 39 in PCP. The parameter most regularly monitored was body mass index (baseline: PSY 88.3%, PCP 97.4%; 12 weeks: PSY 86.4%, PCP 85.0%; and 24 weeks: PSY 91.8%, PCP 100%). Fasting plasma glucose (baseline: PSY 18.9%, PCP 25.6% and 12 weeks: PSY 8.6%, PCP 10.0%) and fasting lipid profile (baseline: PSY 12.7%, PCP 25.6% and 12 weeks: PSY 7.0%, PCP 10.0%) had low completions rates. No difference was seen in metabolic monitoring by sex or ethnic group. CONCLUSIONS: Metabolic monitoring rate of child and adolescent patients on SGAs was low overall. No statistically significant differences were seen between psychiatry and PCP except a significantly higher rate of fasting plasma glucose level monitoring at baseline among PCP. Limitations to the study include the small sample size obtained for the period investigated and insufficient documentation in some electronic charts. Extending the period studied may increase the statistical significance of the data.

Language: eng

Rights:

Pmid: 30762589

Tags: Humans; Female; Male; Retrospective Studies; Child; Adolescent; Child, Preschool; Body Mass Index; Lipids/blood; Antipsychotic Agents/*adverse effects; Blood Glucose/analysis; Weight Gain/drug effects; Guideline Adherence/*statistics & numerical data; Ambulatory Care/standards/statistics & numerical data; Drug Monitoring/standards/*statistics & numerical data; Medical History Taking/standards/statistics & numerical data; Mental Disorders/*drug therapy; Off-Label Use; Pediatric Obesity/blood/chemically induced/*diagnosis/metabolism; Primary Health Care/standards/statistics & numerical data; Psychiatry/standards/statistics & numerical data

Link: https://pubmed.ncbi.nlm.nih.gov/30762589/