In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities.
Autor: Azad, Abul Kalam; Laboni, Farhina Rahman; Rashid, Harun; Ferdous, Sahena; Rashid, Shah Samiur; Kamal, Nurkhalida; Labu, Zubair Khalid; Islam, M. S.; Islam Sarker, Zaidul
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1538216
Abstract:
The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g).
Language: eng
Rights:
Pmid: 30475649
Tags: Humans; Plant Extracts/*pharmacology; Anti-Bacterial Agents/*pharmacology; Antioxidants/*pharmacology; antioxidant; Cell Membrane/drug effects; anti-microbial activity; Bacteria/drug effects/growth & development; Cuscuta reflexa; Cuscuta/*chemistry; Erythrocytes/drug effects; Fibrinolytic Agents/*pharmacology; membrane stabilizing; thrombolytic
Link: https://pubmed.ncbi.nlm.nih.gov/30475649/
