Genetic Polymorphism of HLA-G 14-bp Insertion/Deletion in Pancreas Transplant Recipients and Its Association With Type 1 Diabetes Mellitus.
Autor: Rezaei, Firoozeh; Zareei, Neda; Razmi, Nematollah; Nikeghbalian, Saman; Azarpira, Negar
Publication year: 2021
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
issn:2146-8427 1304-0855
doi: 10.6002/ect.2018.0162
Abstract:
OBJECTIVES: Human leukocyte antigen-G is an immuno-modulatory factor that affects acute allograft rejection and autoimmune diseases such as type 1 diabetes mellitus. In this study, possible associations between human leukocyte antigen-G 14-bp insertion/deletion polymorphism and acute pancreas rejection were investigated. MATERIALS AND METHODS: Human leukocyte antigen-G genotyping was assessed in 102 Iranian pancreas transplant recipients (including 41 with acute rejection and 61 with nonacute rejection). Results were compared with 100 individuals in a normal control group. RESULTS: No significant differences in genotype frequencies of human leukocyte antigen-G 14-bp insertion / deletion were observed in recipients who had acute rejection episodes. On the other hand, the insertion / insertion genotype was a risk factor for susceptibility to type 1 diabetes mellitus (odds ratio = 3.82, 95% confidence interval, 1.37- 11.22; P = .005). CONCLUSIONS: Our results provided evidence revealing that the human leukocyte antigen-G insertion / insertion genotype might be involved in the pathogenesis of type 1 diabetes mellitus.
Language: eng
Rights:
Pmid: 30702046
Tags: Humans; Iran; Genotype; Polymorphism, Genetic; Transplant Recipients; *Diabetes Mellitus, Type 1/diagnosis/genetics; *HLA-G Antigens/genetics; *INDEL Mutation; *Pancreas Transplantation; Graft Rejection/*genetics; Pancreas
Link: https://pubmed.ncbi.nlm.nih.gov/30702046/
