Genetic diversity of HLA system in three populations from Zacatecas, Mexico: Zacatecas city, Fresnillo and rural Zacatecas.
Autor: Hernández-Zaragoza, Diana Iraíz; Delgado-Aguirre, Héctor; Barquera, Rodrigo; Adalid-Sáinz, Carmen; Clayton, Stephen; Lona-Sánchez, Abraham; González-Medina, Liliana; Pacheco-Ubaldo, Hanna; Bravo-Acevedo, Alicia; Escareño-Montiel, Néstor; Morán-Martínez, Javier; Del Rocío González-Martínez, Marisela; Jaramillo-Rodríguez, Yolanda; Juárez-de la Cruz, Federico; Zúñiga, Joaquín; Yunis, Edmond; Bekker-Méndez, Carolina; Granados, Julio
Publication year: 2020
Human immunology
issn:1879-1166 0198-8859
doi: 10.1016/j.humimm.2019.01.007
Abstract:
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 453 Mexicans from the state of Zacatecas living in Zacatecas city (N = 84), Fresnillo (N = 103) and rural communities (N = 266) to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes for the state of Zacatecas include seven Native American most probable ancestry (A*02 ∼ B*39 ∼ DRB1*04 ∼ DQB1*03:02; A*02 ∼ B*35 ∼ DRB1*08 ∼ DQB1*04; A*24 ∼ B*39 ∼ DRB1*14 ∼ DQB1*03:01; A*02 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02; A*24 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02; A*68 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02 and A*24 ∼ B*35 ∼ DRB1*08 ∼ DQB1*04) and two European MPA haplotypes (HLA ∼ A*01 ∼ B*08 ∼ DRB1*03:01 ∼ DQB1*02 and A*29 ∼ B*44 ∼ DRB1*07 ∼ DQB1*02). Admixture estimates revealed that the main genetic components in the state of Zacatecas are European (47.61 ± 1.85%) and Native American (44.74 ± 1.12%), while the African genetic component was less apparent (7.65 ± 1.12%). Our findings provide a starting point for the study of population immunogenetics of urban and rural populations from the state of Zacatecas and add to the growing knowledge on the population genetics of Northern Mexico.
Language: eng
Rights: Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Pmid: 30685399
Tags: Humans; *Polymorphism, Single Nucleotide; Rural Population; Urban Population; Alleles; Haplotypes; White People/genetics; Mexico/ethnology; Admixture; American Indian or Alaska Native/genetics; Black People/genetics; Gene Frequency; Genetics, Population/*methods; Histocompatibility Antigens Class I/*genetics; Histocompatibility Antigens Class II/*genetics; HLA; HLA Antigens/*genetics; Immunogenetics; Linkage Disequilibrium; Population genetics; Zacatecas
Link: https://pubmed.ncbi.nlm.nih.gov/30685399/
