Focal arm weakness following intradetrusor botulinum toxin administration in spinal cord injury: Report of two cases.
Autor: Goodrich, Christopher; York, Henry; Shapiro, Andrew; Gorman, Peter Howard
Publication year: 2020
The journal of spinal cord medicine
issn:2045-7723 1079-0268
doi: 10.1080/10790268.2018.1464693
Abstract:
Context: Outpatient Spinal Cord Injury follow-up practice Findings: We present two cases of individuals with tetraplegia who experienced proximal arm weakness temporally related to the administration of intradetrusor onabotulinumtoxinA without other systemic effects. This arm weakness lasted approximately three months in both cases, whereas the effect of the toxin on the bladder lasted for over six months. In one of the cases, the pattern of proximal arm weakness after intravesicular botulinum toxin injection recurred after repeat injection. Conclusion: These cases represent a previously unreported phenomenon of proximal focal weakness associated with the use of intradetrusor chemodenervation. Possible mechanisms for these cases are discussed.
Language: eng
Rights:
Pmid: 30702394
Tags: Humans; Urodynamics; Arm; *Botulinum Toxins, Type A/adverse effects; *Neuromuscular Agents/adverse effects; *Spinal Cord Injuries/complications/drug therapy; *Urinary Bladder, Neurogenic/drug therapy/etiology; *Urinary Bladder, Overactive; Arm weakness; Botulinum toxin; Chemodenervation; Detrusor overactivity; Neurogenic bladder
Link: https://pubmed.ncbi.nlm.nih.gov/30702394/
