Effects of Transcranial Direct Current Stimulation on Episodic Memory in Amnestic Mild Cognitive Impairment: A Pilot Study.
Autor: Manenti, Rosa; Sandrini, Marco; Gobbi, Elena; Binetti, Giuliano; Cotelli, Maria
Publication year: 2020
The journals of gerontology. Series B, Psychological sciences and social sciences
issn:1758-5368 1079-5014
doi: 10.1093/geronb/gby134
Abstract:
OBJECTIVES: Episodic memory is impaired in amnestic mild cognitive impairment (aMCI), which is posited as a potential prodromal form of Alzheimer’s disease. Reactivated existing memories become sensitive to modification during reconsolidation. There is evidence that the lateral prefrontal cortex (PFC) plays causal role in episodic memory reconsolidation. Transcranial direct current stimulation (tDCS) applied to the PFC after a contextual reminder enhanced episodic memory performance up to 1 month, conceivably through reconsolidation, in older adults with subjective memory complaints, a condition that may represent a “pre-mild cognitive impairment” stage. The aim of this pilot study was to test the effect of PFC-tDCS (anode over left lateral PFC, cathode over right supraorbital area) after a contextual reminder on episodic memory in older adults with aMCI. METHOD: Older adults with aMCI learned a list of words. Twenty-four hours later, tDCS (Active or Sham) was applied after a contextual reminder. Memory retrieval (free recall and recognition) was tested 48 hrs and 1 month after the learning session. RESULTS: Active tDCS enhanced recognition memory relative to Sham stimulation. DISCUSSION: Modulating reconsolidation with PFC-tDCS might be a novel intervention to enhance episodic memories in aMCI.
Language: eng
Rights: © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Pmid: 30395314
Tags: Humans; Aged; Female; Male; Neuropsychological Tests; Pilot Projects; Double-Blind Method; *Memory, Episodic; Mental Recall; Prefrontal cortex; *Transcranial Direct Current Stimulation/methods; Cognitive Dysfunction/psychology/*therapy; Episodic memory; MCI; Memory and Learning Tests; Reconsolidation; tDCS
Link: https://pubmed.ncbi.nlm.nih.gov/30395314/
