Donor-Specific Human Leukocyte Antigen Antibody Formation After Distal Tibia Allograft and Subsequent Graft Resorption.
Autor: Liwski, Christopher R.; Dillman, Daryl; Liwski, Robert S.; Wong, Ivan H.
Publication year: 2020
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
issn:1536-3724 1050-642X
doi: 10.1097/JSM.0000000000000715
Abstract:
The association between donor-specific human leukocyte antigen (HLA) antibody formation and small bone allograft resorption has not been studied. We present the case of a patient treated for glenoid bone loss using a distal tibial allograft with Bankart repair who formed donor-specific HLA antibodies against the allograft and had subsequent graft resorption. X-ray and computed tomography (CT) scans were performed before and after surgery at standard checkpoints. Patient blood and serum samples were collected before and after surgery for HLA typing and HLA antibody testing. Human leukocyte antigen antibodies against the donor-specific HLA-A2 antigens were identified 6 weeks after surgery and were still detected at 5 months after surgery. At 6 months after surgery, a CT arthrogram revealed significant graft resorption. This case shows a temporal correlation between HLA antibody formation and clinical findings, potentially suggesting an association between HLA antibody formation and graft resorption. Further study is required to confirm this.
Language: eng
Rights:
Pmid: 30707112
Tags: Humans; Male; Adolescent; Time Factors; Transplantation, Homologous; Allografts/immunology; Antibodies/*blood/immunology; Bone Resorption/diagnostic imaging/*immunology; HLA-A2 Antigen/*immunology; Host vs Graft Reaction/*immunology; Humeral Head/diagnostic imaging; Shoulder Dislocation/diagnostic imaging; Tibia/*transplantation
Link: https://pubmed.ncbi.nlm.nih.gov/30707112/
