European journal of orthopaedic surgery & traumatology : orthopedie traumatologieByrne, F. J.; Kearns, S. R.; Mulhall, K. J.; McCabe, J. P.; Kaar, K.; Gilmore, M.; O’Sullivan, M.; Curtin, W.journalArticleBTA32IA51432-1068 1633-8065As the age profile of our population expands, we can expect subsequent increase in patients presenting with intracapsular fracture. The onus remains on the surgeon to make all reasonable efforts to find new and innovative means of reducing associated morbidity and mortality of the treatment of these injuries. This challenge is particularly relevant in the elderly and in patients with multiple co-morbidities. In this study, 100 patients were randomly allocated into two groups. One group had dissection to the level of the hip joint under direct diathermy control; the other group had dissection using a scalpel with supplementary electrocautery. Intraoperative total blood loss prior to dissection of the abductors was measured by collecting blood using wound swabs using a local protocol and results were statistically analysed using PROC GLM SAS. We demonstrate a clear advantage in the use of diathermy to create a hip incision showing a significant reduction in wound-related blood loss and a reduction, whilst not statistically significant, in total operative blood loss using diathermy incision. Larger randomised prospective trials are necessary to study the effects of this intervention in a larger patient population so that these end-points can be adequately assessed.engPubMed https://pubmed.ncbi.nlm.nih.gov/23412144/
Pancreatic Cancer-Specific Antigens Discovered for T Cell Therapy
A recent study has identified cancer-specific peptides that can be presented by human leukocyte antigen class I (HLA-I), providing potential targets for T cell therapy in pancreatic cancer treatment. These…
