Decreased platelet-to-lymphocyte ratio as predictor of thrombogenesis in nonvalvular atrial fibrillation.
Autor: Zuo, K.; Yang, X.
Publication year: 2020
Herz
issn:1615-6692 0340-9937
doi: 10.1007/s00059-018-4770-7
Abstract:
BACKGROUND: Inflammation plays a key role in the progression of atrial fibrillation and its related prothrombotic state. The platelet-to-lymphocyte ratio (PLR) is an easily obtainable biomarker of inflammatory burden. Decreased left atrial appendage flow velocity (LAA-FV) reflects blood stasis, and left atrial strain is a manifestation of atrial remodeling. This study examined the role of PLR in reflecting decreased LAA-FV and its correlation with impaired left atrial strain. METHODS: In 54 patients with nonvalvular atrial fibrillation, LAA-FV and left atrial strain were measured by echocardiography. The PLR was calculated from a complete blood count. RESULTS: The PLR was lower in the group of patients with decreased LAA-FV (84.22 [IQR, 69.87-98.17 cm/s] vs. 103.27 [IQR, 90.37-127.16 cm/s]; p = 0.018). PLR was predictive of decreased LAA-FV with a sensitivity of 66.7% and a specificity of 83.3%. In a receiver operator characteristic curve analysis, using a cut-off value of 88.16, the area under the curve for PLR as a predictor of decreased LAA-FV was 0.726 (p = 0.018). Furthermore, the patients with a PLR of < 88.16 had a lower left atrial strain than those with a PLR of > 88.16 (0.38 vs. 0.77, p = 0.02). CONCLUSION: The PLR was lower in patients with nonvalvular atrial fibrillation and with a decreased LAA-FV. Its correlation with left atrial strain might indicate the role of inflammation in the progression of atrial remodeling and in the prothrombotic state.
Language: eng
Rights:
Pmid: 30519706
Tags: Humans; Inflammation; Echocardiography, Transesophageal; Stroke; *Atrial Remodeling; *Atrial Appendage/diagnostic imaging; *Atrial Fibrillation/diagnosis; Atrial remodeling; Lymphocytes; Platelet-to-lymphocyte ratio; Strain
Link: https://pubmed.ncbi.nlm.nih.gov/30519706/
