Cytotoxic triquinane-type sesquiterpenoids from the endophytic fungus Cerrena sp. A593.
Autor: Liu, Hong-Xin; Tan, Hai-Bo; Chen, Yu-Chan; Li, Sai-Ni; Li, Hao-Hua; Zhang, Wei-Min
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1539977
Abstract:
The culture broth of Cerrena sp. A593, which was isolated from Pogostemon cablin, showed potent cytotoxicity against several human tumor cell lines. The following chemical study resulted in the isolation of two new triquinane-type sesquiterpenoids, named cerrenins D (1) and E (2), along with two known compounds plerocybellone A (3) and chloriolin B (4). Their structures were fully assigned with the aid of extensive spectroscopic analysis ((1)H and (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY, HRESIMS, and IR) and data from the literature. Moreover, cytotoxic activity in vitro of compounds 1-4 were evaluated against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound 1 exhibited weak growth inhibitory activity against all the four tumor cell lines with IC(50) values of 41.01, 14.43, 29.67, 44.32 μM.
Language: eng
Rights:
Pmid: 30600698
Tags: Humans; Cell Line, Tumor; Inhibitory Concentration 50; Drug Screening Assays, Antitumor; Molecular Structure; Spectrum Analysis; cytotoxicity; Antineoplastic Agents/chemistry/*isolation & purification/pharmacology; Cerrena sp.; Endophytes/chemistry; Fungi/*pathogenicity; Pogostemon cablin; Pogostemon/microbiology; Sesquiterpenes/chemistry/*isolation & purification/pharmacology; sesquiterpenoids
Link: https://pubmed.ncbi.nlm.nih.gov/30600698/
