CUTICULAR DRUSEN IN AN INDIGENOUS AUSTRALIAN.
Autor: Cunningham, William J.; Balaratnasingam, Chandrakumar; Chen, Yi; Chen, Fred K.
Publication year: 2020
Retinal cases & brief reports
issn:1937-1578 1935-1089
doi: 10.1097/ICB.0000000000000684
Abstract:
BACKGROUND/PURPOSE: To report a case of cuticular drusen in an indigenous Australian. METHODS: A 37-year-old indigenous (aboriginal) Australian woman from a remote Western Australian town presented with a 2-month history of vision loss. Clinical history, examination, and multimodal retinal imaging data from spectral domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography were analyzed. RESULTS: Multimodal imaging confirmed cuticular drusen complicated by a right choroidal neovascularization with pigment epithelial detachment and a left foveal vitelliform lesion. An unusual “negative-staining” pattern was noted on late phase indocyanine green angiography and this spared the regions affected by cuticular drusen. CONCLUSION: To the best of our knowledge, this is the first published report of cuticular drusen in an indigenous Australian. We hypothesize that this may be secondary to ancestral mixing of the gene pool. An unusual staining pattern witnessed on indocyanine green angiography suggests widespread disturbance of lipoprotein deposition in the Bruch membrane.
Language: eng
Rights:
Pmid: 29219932
Tags: Humans; Female; Adult; Fundus Oculi; Tomography, Optical Coherence/methods; Fluorescein Angiography/methods; *Indigenous Peoples; Australia/epidemiology; Bruch Membrane/*pathology; Eye Diseases, Hereditary/*diagnosis/ethnology; Retinal Drusen/*diagnosis/ethnology; Retinal Pigment Epithelium/*pathology
Link: https://pubmed.ncbi.nlm.nih.gov/29219932/
