Chemical constituents isolated from stems of Schisandra chinensis and their antifeedant activity against Tribolium castaneum.
Autor: Guo, Shan-Shan; Pang, Xue; Wang, Yang; Geng, Zhu-Feng; Cao, Ju-Qin; Liang, Jun-Yu; Deng, Zhi-Wei; Du, Shu-Shan
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1547291
Abstract:
One new sesquiterpene (α-iso-cubebenol acetate, 8), together with 9 known compounds (1-7, 9, 10) were isolated from the stems of Schisandra chinensis (Turcz.) Baill. by repeated silica gel column chromatography. Based on the results of MS, NMR spectra and comparing with literature data, the six dibenzocyclooctadiene lignans were identified as schizandrin A to C (1-3), schizandrin (4), schisantherin A (5) and gomisin J (6), the two sesquiterpenes were identified as α-iso-cubebenol (7) and α-iso-cubebenol acetate (8), while the two triterpenic acids were identified as ganwuweizic acid (9) and kadsuric acid (10). The antifeedant activity of the 10 compounds against Tribolium castaneum adults was tested. Gomisin J (6) exhibited activity at 1500 ppm concentration with 40.3% antifeeding index percentages. As for the dibenzocyclooctene lignans (compounds 1-3, 6), the number of methylenedioxies and the position of hydroxyl groups were the main factors to affect their antifeedant activities.
Language: eng
Rights:
Pmid: 30623674
Tags: Animals; Structure-Activity Relationship; *Tribolium/drug effects; antifeedant activity; Cyclooctanes/analysis/*chemistry/isolation & purification; dibenzocyclooctadiene lignans; Dioxoles/isolation & purification; Feeding Behavior/*drug effects; Lignans/analysis/*chemistry/isolation & purification; Plant Stems/*chemistry; Polycyclic Compounds/isolation & purification; Schisandra chinensis (Turcz.) Baill; Schisandra/*chemistry; Sesquiterpenes/analysis/isolation & purification; Tribolium castaneum; Triterpenes/analysis/isolation & purification; α-iso-cubebenol acetate
Link: https://pubmed.ncbi.nlm.nih.gov/30623674/
