Biological activities and chemical components of Potentilla kleiniana Wight & Arn.
Autor: Xuan, Song Hua; Hong, In Ki; Lee, Yun Ju; Kim, Ji Woong; Park, Soo Nam
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1557171
Abstract:
In this study, we investigated the antimicrobial, antioxidant, and cytoprotective activities of ethanol extract and the ethyl acetate (EtOAc) fraction of P. kleiniana Wight & Arn. The EtOAc fraction exhibited antimicrobial effects against most of the microorganisms that were tested, including Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, and, Escherichia coli, but not Aspergillus niger. In addition to its excellent antioxidant activity, the EtOAc fraction attenuated the UVB-induced cell death via upregulation of caspase-3 expression in human keratinocytes. The HPLC/ESI-MS/MS analysis allowed identification of the components in the EtOAc fraction. Overall, our results suggest that P. kleiniana is a valuable source of bioactive compounds for the development of pharmaceuticals and cosmetics.
Language: eng
Rights:
Pmid: 30663365
Tags: Humans; Microbial Sensitivity Tests; Ultraviolet Rays/adverse effects; Caspase 3/metabolism; Tandem Mass Spectrometry; Chromatography, High Pressure Liquid/methods; Ethanol/chemistry; antioxidant; Cytoprotection; Cell Line; Drug Evaluation, Preclinical; Escherichia coli/drug effects; Staphylococcus aureus/drug effects; antimicrobial activity; Candida albicans/drug effects; Plant Extracts/*chemistry/pharmacology; Antioxidants/chemistry/*pharmacology; Anti-Infective Agents/chemistry/*pharmacology; Anti-Bacterial Agents/pharmacology; Pseudomonas aeruginosa/drug effects; Aspergillus niger/drug effects; caspase-3; cytoprotective activities; Keratinocytes/drug effects/metabolism/radiation effects; Potentilla kleiniana Wight & Arn.; Potentilla/*chemistry
Link: https://pubmed.ncbi.nlm.nih.gov/30663365/
