Auroglaucin-related neuroprotective compounds from Vietnamese marine sediment-derived fungus Aspergillus niveoglaucus.
Autor: Yurchenko, Anton N.; Smetanina, Olga F.; Ivanets, Elena V.; Phan, Trinh Thi Hoai; Ngo, Ngoc Thi Duy; Zhuravleva, Olesya I.; Rasin, Anton B.; Dyshlovoy, Sergey A.; Menchinskaya, Ekaterina S.; Pislyagin, Eugeny A.; von Amsberg, Gunhild; Afiyatullov, Shamil Sh; Yurchenko, Ekaterina A.
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2018.1547293
Abstract:
Two new auroglaucin-derived compounds, niveoglaucins A (1) and B (2), together with four known related compounds were isolated from extract of the marine sediment-derived strain of Aspergillus niveoglaucus. The structures of these compounds were determined by 1D and 2D NMR spectroscopy and high resolution MS. The plausible biosynthetic pathway was proposed for new compounds 1 and 2. The neuroprotective activity in 6-OHDA-induced Parkinson’s disease cell model was shown for niveoglaucin A (1).
Language: eng
Rights:
Pmid: 30623671
Tags: Humans; Animals; Mice; Parkinson’s disease; Models, Biological; Vietnam; Magnetic Resonance Spectroscopy; Molecular Structure; Mass Spectrometry; Cell Line; Antiparkinson Agents/isolation & purification; Aspergillus niveoglaucus; Aspergillus/*chemistry; Eurotium niveoglaucum; Fungi/chemistry; Geologic Sediments/*chemistry/microbiology; marine-derived fungus; neuroprotective activity; Neuroprotective Agents/chemistry/*isolation & purification/pharmacology; Oxidopamine/adverse effects; Parkinsonian Disorders/chemically induced/drug therapy/pathology; secondary metabolites
Link: https://pubmed.ncbi.nlm.nih.gov/30623671/
