Assessment of Bone and Muscle Measurements by Peripheral Quantitative Computed Tomography in Geriatric Patients.
Autor: Drey, M.; Henkel, M.; Petermeise, S.; Weiß, S.; Ferrari, U.; Rottenkolber, M.; Schmidmaier, R.
Publication year: 2020
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
issn:1094-6950
doi: 10.1016/j.jocd.2018.10.002
Abstract:
The loss of bone and muscle mass increases the risk of osteoporotic fractures. Dual energy X-ray absorptiometry (DXA) loses sensitivity in older age. The purpose of this study was to evaluate bone and muscle measurements of peripheral quantitative computed tomography (pQCT) in a geriatric cohort with osteoporosis. Bone mineral density and muscle area of 168 patients aged 65 years and older (76.3 ± 6.5) were measured with pQCT at distal forearm additionally to an osteoporosis assessment consisting of anamnesis, blood test and DXA of lumbar spine and hip. Prior fractures were categorized in minor and major osteoporotic fractures. Logistic regression was used to show the association of bone mineral density and muscle area with major fractures. 54.8% of the participants had at least one major fracture. Bone mineral density measured with pQCT and muscle area were significantly associated with these fractures (total and trabecular bone mineral density OR 2.243 and 2.195, p < 0.01; muscle area OR 2.378, p < 0.05), whereas DXA bone mineral density showed no significant association. These associations remained after adjustment for age, sex, BMI, physical activity and other factors. In all models for patients >75 years only muscle area was significantly associated (OR 5.354, p < 0.05) with major fractures. Measurement of bone mineral density and muscle area with pQCT seems to have advantage over DXA in fracture association in geriatric patients. Measuring muscle area also adds useful information to estimate the presence of osteosarcopenia. Language: eng Rights: Copyright © 2018 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. Pmid: 30425007 Tags: Humans; Aged; Aged, 80 and over; Female; Male; Bone Density; Tomography, X-Ray Computed/methods; Absorptiometry, Photon; sarcopenia; osteoporosis; DXA; Cancellous Bone/anatomy & histology/diagnostic imaging; Lumbar Vertebrae/diagnostic imaging/pathology; Muscle, Skeletal/*diagnostic imaging/pathology; Osteoporosis/diagnostic imaging/pathology; Osteoporotic Fractures/diagnostic imaging/pathology; osteosarcopenia; Pelvic Bones/diagnostic imaging/pathology; pQCT; Radius/*diagnostic imaging/pathology Link: https://pubmed.ncbi.nlm.nih.gov/30425007/
