AQUEOUS HUMOR CYTOKINES AND THERAPEUTIC CUSTOMIZATION IN NONRESPONDING MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION.
Autor: Modi, Aditya; Sharma, Karen; Sudhakar, Neha Peraka; Yadav, Naresh Kumar
Publication year: 2021
Retinal cases & brief reports
issn:1937-1578 1935-1089
doi: 10.1097/ICB.0000000000000768
Abstract:
AIM: To report an alternative cytokine-based customized therapeutic approach of macular edema secondary to retinal vein occlusion. METHODS: A 64-year-old male patient presented with left eye macular edema secondary to central retinal vein occlusion, status after three consecutive anti-vascular endothelial growth factor injections. He was subsequently subjected to aqueous humor cytokine analysis. Vascular endothelial growth factor, interleukin-6 (IL-6), and interleukin-8 (IL-8) concentrations were determined using multiplex bead assay (BD Cytometric Bead Array). Based on the results, intravitreal steroid was administered. Follow-up examination included monitoring corrected distance visual acuity using Snellen’s chart, central subfoveal thickness measurement on spectral domain optical coherence tomography (Spectralis, HRA2; Heidelberg engineering, Heidelberg, Germany) and cytokine quantification at the end of one and three months. RESULTS: Baseline corrected distance visual acuity was counting fingers at 1 m, which subsequently improved to 6/12 Snellen equivalent 1 month after customized intravitreal therapy. Central subfoveal thickness demonstrated significant reduction from 529 to 253 µm; baseline vascular endothelial growth factor, IL-6, and IL-8 concentration were ascertained to be 29.94, 1.31, and 82.12 pg/mL (picograms/millilitre). One month after intravitreal steroid injection, the IL-8 levels normalized to 13.28 pg/mL. Functional and anatomical improvements were sustained till the last follow-up at 3 months. CONCLUSION: Customized intravitreal treatment provides an objective, alternative, and effective therapeutic approach for macular edema secondary to retinal vein occlusion.
Language: eng
Rights:
Pmid: 30664079
Tags: Humans; Male; Middle Aged; Tomography, Optical Coherence; Fluorescein Angiography; Ophthalmoscopy; Intravitreal Injections; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Visual Acuity/physiology; Intraocular Pressure/physiology; Angiogenesis Inhibitors/*therapeutic use; Cytokines/*metabolism; Aqueous Humor/*metabolism; Macular Edema/diagnostic imaging/*drug therapy/etiology/metabolism; Ranibizumab/*therapeutic use; Retinal Vein Occlusion/complications/diagnostic imaging/*drug therapy/metabolism
Link: https://pubmed.ncbi.nlm.nih.gov/30664079/
