A new pentacyclic triterpenoid from the leaves of Rhododendron dauricum L. with inhibition of NO production in LPS-induced RAW 264.7 cells.
Autor: Wang, Jiaming; Jin, Mei; Jin, Chunshi; Ye, Chao; Zhou, Yi; Wang, Rongshen; Cui, Huanhuan; Zhou, Wei; Li, Gao
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2019.1566822
Abstract:
A new pentacyclic triterpenoid, 3-oxo-urs-11,13(18)-dien-28-oic acid (1), along with twelve known triterpenoids, α-amyrin (2), 19α-hydroxy-α-amyrin (3), triptohypol E (4), uvaol (5), 2α,3α-dihydroxyurs-11-en-13β,28-olide (6), 3β-hydroxyurs-11-en-13β,28-olide (7), ursolic acid (8), asiatic acid (9), oleanolic acid (10), aegiceradienol (11), obtusalin (12) and betulinic acid (13) were isolated from the leaves of Rhododendron dauricum L. Their structures were established from spectroscopic data and comparison with reported values. Among them, compounds 3, 4, 6, 7 and 11 were isolated from the Ericaceae family for the first time. Compounds 2, 5, 9, 12 and 13 were obtained from R. dauricum for the first time. Additionally, compounds 6, 10 and 11 significantly inhibited the levels of NO in LPS-stimulated RAW 264.7 cells at 3 μM.
Language: eng
Rights:
Pmid: 30810367
Tags: Animals; Mice; Molecular Structure; Plant Leaves/chemistry; Drug Evaluation, Preclinical; Plant Extracts/chemistry; Anti-Inflammatory Agents, Non-Steroidal/chemistry/*pharmacology; RAW 264.7 Cells; Ursolic Acid; NO; triterpenoid; Lipopolysaccharides/pharmacology; Betulinic Acid; Ericaceae; Nitric Oxide/antagonists & inhibitors/*biosynthesis; Oleanolic Acid/analysis; Pentacyclic Triterpenes/analysis; Rhododendron dauricum L.; Rhododendron/*chemistry; Triterpenes/analysis/*chemistry/*pharmacology
Link: https://pubmed.ncbi.nlm.nih.gov/30810367/
