A new epicatechin glucopyranoside derivative from Styrax suberifolius.
Autor: Liu, Bing-Lei; Hu, Xin; He, Hua-Liang; Qiu, Lin; Li, You-Zhi; Ding, Wen-Bing
Publication year: 2020
Natural product research
issn:1478-6427 1478-6419
doi: 10.1080/14786419.2019.1569011
Abstract:
A new derivative of epicatechin glucopyranoside, (2R,3R)-3,7,4′-trihydroxy-5,3′-dimethoxyflavan 7-O-β-d-glucopyranoside (1), together with three mononuclear phenolic acid esters, methyl orsellinate (2), ethyl orsellinate (3) and methyl β-orcinolcarboxylate (4) were isolated from the bark of Styrax suberifolius. The structures of 1-4 were determined on the basis of extensive analysis of NMR and MS spectra combined with chemical hydrolysis. The antifungal activities of the isolated compounds against three plant pathogenic fungi, Alternaria solani, Fusarium oxysporum and Phomopsis cytospore were evaluated using radial growth inhibition assay. Compounds 2, 3 and 4 exerted selective inhibitory activities against the tested fungi. Among of them, methyl β-orcinolcarboxylate (4) exhibited obvious inhibitory effect against P. cytospore, with an inhibition rate of 86.72% at 100 μg/ml.
Language: eng
Rights:
Pmid: 30732479
Tags: Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Extracts/chemistry; antifungal activity; Antifungal Agents/*isolation & purification/pharmacology; Fungi/drug effects; Alternaria/drug effects; Catechin/chemistry/*isolation & purification/pharmacology; epicatechin derivative; flavonoid glycoside; Fusarium/drug effects; Styrax suberifolius; Styrax/*chemistry
Link: https://pubmed.ncbi.nlm.nih.gov/30732479/
