Trending News: COVID-19 Case Rates in Chicago: Vaccinated vs UnvaccinatedPresident Trump Open to Further Delays on TikTok BanTrump Extends Trade War Rhetoric to Entertainment IndustryDuolingo Shifts to AI-First Strategy, Replacing Contractors with Artificial IntelligenceU.S. Stock Futures Dip After S&P 500 Hits Record HighAirbnb Launches AI Customer Service Bot in the U.S.DUST ETF: Short-Term Hedge Against Gold, But Long-Term Bullish Outlook RemainsAI-Crypto Convergence Sparks Growing Investor InterestAI Analyzes Art With Deeper Insight Than Human Eye, Researchers SayPresident Criticizes Foreign Films for U.S. Film Industry DeclineUC Berkeley Police Investigate Stabbing Near Lawrence Hall of ScienceOcean Discovery Institute Lays Off AmeriCorps Teachers Due to Federal Budget CutsVenezuelan Deputy Science Minister Visits Iran to Boost Bilateral CooperationIFLScience Commits to Educating and Sparking Curiosity WorldwideInside Apple’s Cork R&D Lab: A Look at Product Longevity 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Motors Recalls Nearly 600,000 Trucks and SUVs Over Engine DefectUnderstanding Mutual Funds as an Investment StrategyMarvel’s ‘Thunderbolts’ Tops Box Office With $76 Million DebutRevelo Sees New Wave of Growth as Demand Rises for LLM Training TalentWarren Buffett Leads Berkshire Hathaway for Six Decades, Building Trillion-Dollar EmpireQUALCOMM, ServiceNow, and Super Micro Computer Identified as Key AI Stocks to WatchSustainable Investing Remains Resilient Amid Market Challenges, Says Mirova ExecutiveU.S. Stock Market Rebounds to Pre-‘Liberation Day’ LevelsUS Stock Market Recovers to Trump’s ‘Liberation Day’ LevelsTariffs and Geopolitics Top Business Concerns as AI Transforms Supply ChainsWall Street Strategists Question ‘Sell in May’ Market AdageTwo Promising AI Stocks Poised for Long-Term GrowthHumor as a Coping Mechanism: ‘Recession Indicator’ Memes Go Viral Amid Economic UncertaintyRoblox Demonstrates Strong Growth Potential in Gaming and Metaverse SectorSustainable Investing Remains Strong Despite Market ChallengesCarmel High School Seniors Present Research at Prestigious Science CompetitionsAstronomers Detect Rare Cosmic Blasts That Could Signal Exotic Black HolesDire Wolves Spark Ethical Debate in Genetic EngineeringIran Prioritizes Scientific Collaboration with Neighboring NationsChemistry Teacher Builds Strong Bonds With Students Beyond the ClassroomWarren Buffett-Backed Stocks That Can Weather Any Market ConditionsS&P 500 Achieves Longest Winning Streak in Two DecadesState-Backed Group Ramps Up Investment in AI CollaborationNew AI Tools Aim to Help Workers Navigate Career TransitionsBerkshire Hathaway Shareholders Express Concern Over Buffett’s DepartureStock Viewed as Bargain Compared to S&P 500 PeersGen Z Turns to Hermès Birkin Bags as Alternative Investment, Driven by TikTok FrenzyStock Undervalued Compared to S&P 500 PeersComparing Rates of Diagnosis Using DSM-IV-TR Versus DSM-5 Criteria for Autism Spectrum Disorder.Blindness and Autism: Parents’ Perspectives on Diagnostic Challenges, Support Needs and Support Provision.A Behavior Sequence Analysis of Victims’ Accounts of Stalking Behaviors.Breaking the Taboo: Sexual Assault in Late Life as a Multifaceted Phenomenon-Toward an Integrative Theoretical Framework.Associations Between Rejection Sensitivity, Aggression, and Victimization: A Meta-Analytic Review.Influence of physical and psychosocial working conditions for the risk of disability pension among healthy female eldercare workers: Prospective cohort.Psychometric Properties of Two Brief Versions of Cognitive, Insomnia-Specific Measures: The Anxiety and Preoccupation About Sleep Questionnaire and the Sleep-Associated Monitoring Index.Emotional Intelligence Moderates Anhedonia and Suicidal Ideation in Depressed Patients.An Analysis of Psychoactive Medications Initiated in the ICU but Continued Beyond Discharge: A Pilot Study of Stewardship.Impact of a Pharmacy-Initiated Inpatient Diabetes Patient Education Program on 30-Day Readmission Rates.Preadmission Corticosteroid Therapy and the Risk of Respiratory Failure in Adults Without HIV Presenting With Pneumocystis Pneumonia.Trends in Hospital Admissions for Intimate Partner Violence in Australian Mothers With Children Born From 1990 to 2009.How People Forgive: A Systematic Review of Nurse-Authored Qualitative Research.A Biomechanical Comparison of Fiberglass Casts and 3-Dimensional-Printed, Open-Latticed, Ventilated Casts.The Family Resilience Inventory: A Culturally Grounded Measure of Current and Family-of-Origin Protective Processes in Native American Families.Disseminating Tai Chi in the Community: Promoting Home Practice and Improving Balance.A re-evaluation of teenage sunbed use following the introduction of banning legislation for under 18-year-olds.Evaluation of the efficiency of Boston brace on scoliotic curve control: A review of literature.Validity of the Apple Watch(®) for monitoring push counts in people using manual wheelchairs.Anaerobic digestion of bean straw applying a fungal pre-treatment and using cow manure as co-substrate.Diabetes Mellitus-Associated Uveitis: Clinical Features in a Chilean Series.Desegregation and the retreat of clinical psychoanalysis.Effects of Cognitive Behavioral Therapy for Reducing Anxiety in Children with High Functioning ASD: A Systematic Review and Meta-Analysis.[Between red tape and scalpel : Urological literature, denazification and censorship in East Germany in the early postwar period].Comparison of fracture healing and long-term patient-reported functional outcome between dorsal and volar plating for AO C3-type distal radius fractures.Acquisition of a phospho-acceptor site enhances HPV E6 PDZ-binding motif functional promiscuity.Can devices for the instrumental analysis of temporomandibular joints be used interchangeably?Obesity effects on muscular activity during lifting and lowering tasks.Decompression of Ludwig’s angina in a pregnant patient under bilateral superficial cervical plexus block.The weekly calendar planning activity in multiple sclerosis: A top-down assessment of executive functions.Cohort profile – MSK radiation workers: a feasibility study to establish a deceased worker sub-cohort as part of a multicenter medical radiation worker component in the million person study of low-dose radiation health effects.Reasons for elective cesarean section on maternal request: a systematic review.Early development of the human placenta and pregnancy complications.A comparison of cervical ripening modalities among overweight and obese nulliparous gravidas.Human milk mycotoxin contamination: smoking exposure and breastfeeding problems.Effect of interpregnancy interval after a first pregnancy complicated by placental abruption, on adverse maternal and fetal outcomes in a second pregnancy.Elevated expression of EP4 in human decidua is associated with delayed embryo expulsion during medical abortion by promoting decidual cell proliferation.Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge.Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.Determination of serum aflatoxin B(1)-lysine and biochemical parameters in broiler chicks fed an aflatoxin B(1)-contaminated diet.New p-terphenyl and benzoquinone metabolites from the bioluminescent mushroom Neonothopanus nambi.A new pentacyclic triterpenoid from the leaves of Rhododendron dauricum L. with inhibition of NO production in LPS-induced RAW 264.7 cells.
Mon. May 5th, 2025
Trending News: COVID-19 Case Rates in Chicago: Vaccinated vs UnvaccinatedPresident Trump Open to Further Delays on TikTok BanTrump Extends Trade War Rhetoric to Entertainment IndustryDuolingo Shifts to AI-First Strategy, Replacing Contractors with Artificial IntelligenceU.S. Stock Futures Dip After S&P 500 Hits Record HighAirbnb Launches AI Customer Service Bot in the U.S.DUST ETF: Short-Term Hedge Against Gold, But Long-Term Bullish Outlook RemainsAI-Crypto Convergence Sparks Growing Investor InterestAI Analyzes Art With Deeper Insight Than Human Eye, Researchers SayPresident Criticizes Foreign Films for U.S. Film Industry DeclineUC Berkeley Police Investigate Stabbing Near Lawrence Hall of ScienceOcean Discovery Institute Lays Off AmeriCorps Teachers Due to Federal Budget CutsVenezuelan Deputy Science Minister Visits Iran to Boost Bilateral CooperationIFLScience Commits to Educating and Sparking Curiosity WorldwideInside Apple’s Cork R&D Lab: A Look at Product Longevity InnovationsStock Futures Start the Week Flat Ahead of Key Economic DataMark Zuckerberg Highlights AI’s Role in Enhancing Human RelationshipsGlobal Press Freedom Under Threat Amid Rising Violence and CensorshipWhy a 5% Bitcoin Allocation May Strengthen Your Investment PortfolioPresident Trump Open to Further Delaying TikTok Ban, Report SaysTomatoes Recalled in 11 States Over Salmonella ConcernsUncork Capital Closes $300 Million Across Two New FundsDuolingo Shifts to AI-First Strategy, Plans to Replace Human ContractorsMirova Launches New Nature-Based Carbon Funds Amid Growing Interest in ESG InvestingAirbnb Launches AI-Powered Customer Service Tool in the U.S.Richard Sternberg’s Research Challenges Traditional Views of the GenomeThree Suspects Flee Scene After Incident Near UC BerkeleyMonthly Wildlife Education Classes Offered for Homeschooled ChildrenGrassroots Movement Aims to Bring Astronomy to the PublicUC Police Investigate Stabbing Near Lawrence Hall of Science in BerkeleyGeneral Motors Recalls Nearly 600,000 Trucks and SUVs Over Engine DefectUnderstanding Mutual Funds as an Investment StrategyMarvel’s ‘Thunderbolts’ Tops Box Office With $76 Million DebutRevelo Sees New Wave of Growth as Demand Rises for LLM Training TalentWarren Buffett Leads Berkshire Hathaway for Six Decades, Building Trillion-Dollar EmpireQUALCOMM, ServiceNow, and Super Micro Computer Identified as Key AI Stocks to WatchSustainable Investing Remains Resilient Amid Market Challenges, Says Mirova ExecutiveU.S. Stock Market Rebounds to Pre-‘Liberation Day’ LevelsUS Stock Market Recovers to Trump’s ‘Liberation Day’ LevelsTariffs and Geopolitics Top Business Concerns as AI Transforms Supply ChainsWall Street Strategists Question ‘Sell in May’ Market AdageTwo Promising AI Stocks Poised for Long-Term GrowthHumor as a Coping Mechanism: ‘Recession Indicator’ Memes Go Viral Amid Economic UncertaintyRoblox Demonstrates Strong Growth Potential in Gaming and Metaverse SectorSustainable Investing Remains Strong Despite Market ChallengesCarmel High School Seniors Present Research at Prestigious Science CompetitionsAstronomers Detect Rare Cosmic Blasts That Could Signal Exotic Black HolesDire Wolves Spark Ethical Debate in Genetic EngineeringIran Prioritizes Scientific Collaboration with Neighboring NationsChemistry Teacher Builds Strong Bonds With Students Beyond the ClassroomWarren Buffett-Backed Stocks That Can Weather Any Market ConditionsS&P 500 Achieves Longest Winning Streak in Two DecadesState-Backed Group Ramps Up Investment in AI CollaborationNew AI Tools Aim to Help Workers Navigate Career TransitionsBerkshire Hathaway Shareholders Express Concern Over Buffett’s DepartureStock Viewed as Bargain Compared to S&P 500 PeersGen Z Turns to Hermès Birkin Bags as Alternative Investment, Driven by TikTok FrenzyStock Undervalued Compared to S&P 500 PeersComparing Rates of Diagnosis Using DSM-IV-TR Versus DSM-5 Criteria for Autism Spectrum Disorder.Blindness and Autism: Parents’ Perspectives on Diagnostic Challenges, Support Needs and Support Provision.A Behavior Sequence Analysis of Victims’ Accounts of Stalking Behaviors.Breaking the Taboo: Sexual Assault in Late Life as a Multifaceted Phenomenon-Toward an Integrative Theoretical Framework.Associations Between Rejection Sensitivity, Aggression, and Victimization: A Meta-Analytic Review.Influence of physical and psychosocial working conditions for the risk of disability pension among healthy female eldercare workers: Prospective cohort.Psychometric Properties of Two Brief Versions of Cognitive, Insomnia-Specific Measures: The Anxiety and Preoccupation About Sleep Questionnaire and the Sleep-Associated Monitoring Index.Emotional Intelligence Moderates Anhedonia and Suicidal Ideation in Depressed Patients.An Analysis of Psychoactive Medications Initiated in the ICU but Continued Beyond Discharge: A Pilot Study of Stewardship.Impact of a Pharmacy-Initiated Inpatient Diabetes Patient Education Program on 30-Day Readmission Rates.Preadmission Corticosteroid Therapy and the Risk of Respiratory Failure in Adults Without HIV Presenting With Pneumocystis Pneumonia.Trends in Hospital Admissions for Intimate Partner Violence in Australian Mothers With Children Born From 1990 to 2009.How People Forgive: A Systematic Review of Nurse-Authored Qualitative Research.A Biomechanical Comparison of Fiberglass Casts and 3-Dimensional-Printed, Open-Latticed, Ventilated Casts.The Family Resilience Inventory: A Culturally Grounded Measure of Current and Family-of-Origin Protective Processes in Native American Families.Disseminating Tai Chi in the Community: Promoting Home Practice and Improving Balance.A re-evaluation of teenage sunbed use following the introduction of banning legislation for under 18-year-olds.Evaluation of the efficiency of Boston brace on scoliotic curve control: A review of literature.Validity of the Apple Watch(®) for monitoring push counts in people using manual wheelchairs.Anaerobic digestion of bean straw applying a fungal pre-treatment and using cow manure as co-substrate.Diabetes Mellitus-Associated Uveitis: Clinical Features in a Chilean Series.Desegregation and the retreat of clinical psychoanalysis.Effects of Cognitive Behavioral Therapy for Reducing Anxiety in Children with High Functioning ASD: A Systematic Review and Meta-Analysis.[Between red tape and scalpel : Urological literature, denazification and censorship in East Germany in the early postwar period].Comparison of fracture healing and long-term patient-reported functional outcome between dorsal and volar plating for AO C3-type distal radius fractures.Acquisition of a phospho-acceptor site enhances HPV E6 PDZ-binding motif functional promiscuity.Can devices for the instrumental analysis of temporomandibular joints be used interchangeably?Obesity effects on muscular activity during lifting and lowering tasks.Decompression of Ludwig’s angina in a pregnant patient under bilateral superficial cervical plexus block.The weekly calendar planning activity in multiple sclerosis: A top-down assessment of executive functions.Cohort profile – MSK radiation workers: a feasibility study to establish a deceased worker sub-cohort as part of a multicenter medical radiation worker component in the million person study of low-dose radiation health effects.Reasons for elective cesarean section on maternal request: a systematic review.Early development of the human placenta and pregnancy complications.A comparison of cervical ripening modalities among overweight and obese nulliparous gravidas.Human milk mycotoxin contamination: smoking exposure and breastfeeding problems.Effect of interpregnancy interval after a first pregnancy complicated by placental abruption, on adverse maternal and fetal outcomes in a second pregnancy.Elevated expression of EP4 in human decidua is associated with delayed embryo expulsion during medical abortion by promoting decidual cell proliferation.Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge.Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.Determination of serum aflatoxin B(1)-lysine and biochemical parameters in broiler chicks fed an aflatoxin B(1)-contaminated diet.New p-terphenyl and benzoquinone metabolites from the bioluminescent mushroom Neonothopanus nambi.A new pentacyclic triterpenoid from the leaves of Rhododendron dauricum L. with inhibition of NO production in LPS-induced RAW 264.7 cells.
Mon. May 5th, 2025

Inhibitory potential of Hydroxychavicol on Ehrlich ascites carcinoma model and in silico interaction on cancer targets.

Inhibitory potential of Hydroxychavicol on Ehrlich ascites carcinoma model and in silico interaction on cancer targets.

Autor: Hemamalini, Vedagiri; Velayutham, Dass Prakash M.; Lakshmanan, Loganathan; Muthusamy, Karthikeyan; Sivaramakrishnan, Sivaperumal; Premkumar, Kumpati

Publication year: 2020

Natural product research

issn:1478-6427 1478-6419

doi: 10.1080/14786419.2018.1519819

Abstract:

Hydroxychavicol (HC), a major phenolic derivative isolated from the leaves of Piper betle L. is well known for its antibacterial, antifungal and antimutagenic properties. The present study evaluated the in vivo antitumor activity of HC against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice and in silico interaction of HC with the receptors involved in the cancer. Hydroxychavicol (200 and 400 mg/kg bw) was orally administered for 21 consecutive days and was effective in inhibiting the tumor growth in ascitic mouse model. HC consistently reduced the tumor volume, viable cell count, lipid peroxidation and elevated the life span of HC treated mice. Besides the hematological profiles, SGOT and SGPT levels reverted back to normal and oxidative stress markers GSH, SOD and CAT also increased in HC treated groups. In silico docking analysis revealed that HC possessed potent antagonist activity against all the cancer targets demonstrating its inhibitory activity.

Language: eng

Rights:

Pmid: 30470141

Tags: Female; Animals; Mice; Oxidative stress; Superoxide Dismutase/metabolism; Antitumor; Computer Simulation; Lipid Peroxidation/drug effects; Oxidative Stress/drug effects; Glutathione/metabolism; Molecular Docking Simulation; Antineoplastic Agents, Phytogenic/administration & dosage/*pharmacology; Carcinoma, Ehrlich Tumor/*drug therapy/pathology; Catalase/metabolism; Docking; Ehrlich Ascites Carcinoma; ErbB Receptors/antagonists & inhibitors/metabolism; Eugenol/administration & dosage/*analogs & derivatives/chemistry/pharmacology; Hydroxychavicol; Piper betle/chemistry; Plant Extracts/pharmacology; Receptors, CXCR4/antagonists & inhibitors/metabolism

Link: https://pubmed.ncbi.nlm.nih.gov/30470141/

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